Seventy-seven seconds on the clock and 78 yards to go. Mission Impossible. Or at the least, improbable.

Not so Sunday, not for the Indianapolis Colts with quarterback Peyton Manning pulling the trigger. The Colts went the distance with three seconds to spare for a door-slamming, end-of-the-half touchdown in a 34-17 manhandling of the Seattle Seahawks before a sellout crowd of 66,112 at Lucas Oil Stadium.

“We played greatness today, one of the finest of all time,” Seattle coach Jim Mora gushed of Manning. “He proves it over and over again. Regardless of the circumstances, he comes up with the play.”

Manning was 7-for-9 on the series and one of the incompletions was a throwaway. He threw for 93 yards on a 78-yard drive. Holding and delay-of-game penalties only stopped the clock and abetted the effort. Magic wore No. 18.

The last pass was a 21-yard touchdown to Austin Collie, the rookie wide receiver’s first in the NFL and the spike to the heart that put the Seahawks in a 21-3 halftime hole. It also was a window on Manning’s world.

“They blitzed on the play before and played man-to-man coverage,” said Manning, who completed 31-of-41 passes for 353 yards and two touchdowns with one interception.

“We’re not 100 percent sure they’re going to do it again but just in case they do, we kind of had an answer for man-to-man on the right side and we kind of had an answer for zone on the left.”

Wearing pink wristbands in concert with the NFL’s support of Breast Cancer Awareness Month, Manning turned toward Collie, in the slot to the right side, and shouted a pass route adjustment. Collie ran a fade into the corner of the end zone. He easily beat cornerback Travis Fisher and made a laid-out catch on a pretty pass.

“He’s extremely smart, he does the film work that he needs to be doing. He’s always on top of things, always seeing things,” Collie said of Manning. “I think that’s what makes him the best.”

The Colts (4-0) maintained their two-game edge in the AFC South. They pushed the NFL’s longest current regular-season winning streak to 13 games and tied a club record in the process. They matched their 13-0 start in 2005 for the longest run in team’s 57 years of NFL membership.

Next up is a Sunday night show at AFC South defending champion Tennessee (0-4), the Colts’ third prime-time appearance in four games.

Seattle (1-3) arrived at Lucas Oil Stadium gutted by injury and playing backup quarterback Seneca Wallace. The Colts pounced.

They allowed the Seahawks 49 yards on 19 rushes, a 2.6-yard average, and with the fat early lead, attacked with their pass rush. End Robert Mathis had three sacks and end Dwight Freeney and linebacker Freddy Keiaho had one each.

Seattle didn’t cross the goal line until the final three minutes, when it did so twice. Meanwhile, Manning threw for more than 300 yards a club-record fourth consecutive game.

A first-game knee injury to No. 2 wide receiver Anthony Gonzalez figured to be crippling, but the Colts offense hasn’t looked back. Manning hit five different receivers with his first five passes on the final drive of the first half.

Tight end Dallas Clark, running back Joseph Addai, wide receiver Reggie Wayne and Collie each had six or more catches for 50 or more yards. Second-year receiver Pierre Garcon caught three passes for 71 yards.

And with Manning calling the shots and making the throws, they have thrived in the most intense pressure situations.

The 78-yard drive at the end of the half was the Colts’ fifth two-minute drill of the young season. Manning is 16-for-22 (72.7 percent) for 286 yards and two touchdowns on those series. The Colts have scored on four of the five: three touchdowns and a field goal.

The line has protected, Manning has pitched strikes and the receivers have found openings, made catches and gotten out of bounds.

An old pal was watching in admiration from the Seattle sideline Sunday. Seahawks running back Edgerrin James became the Colts’ career rushing leader while taking handoffs from Manning from 1999-2005.

“That’s my boy, man, ‘P,’ " Edge said. “I’ve always said ‘P’ is the best quarterback ever to play the game. That’s how I feel.”

Seventy-seven seconds on the clock and 78 yards to go: “P” is for possible.