This weekend the Colts face the Carolina Panthers, a team the Colts haven't played for 4 years. A team Peyton Manning has never beaten (0-4), and a team who has never hosted the Indianapolis Colts.

Suffice it to say, Carolina is an unfamiliar team, and one with decent players on both sides of the ball. So what's your prediction? Do you think the Colts will win this one on the road, during a short week? Do you feel this could be the Colts first loss? Or will we go undefeated into quite possibly the biggest game of the season hosting New England at home? (By the way, I am calling the New England game the mid-season Superbowl.)

My pick is a win in Carolina, 28-14. What's yours?

By the way, if you want to continue your Colts support, visit JerseyChallenge.com where we are trying to raise $25,000 for the Peyton Manning Children's Hospital at St. Vincent.